Regulation of RKIP Function by Helicobacter pylori in Gastric Cancer
نویسندگان
چکیده
منابع مشابه
Regulation of RKIP Function by Helicobacter pylori in Gastric Cancer
Helicobacter pylori (H. pylori) is a gram-negative, spiral-shaped bacterium that infects more than half of the world's population and is a major cause of gastric adenocarcinoma. The mechanisms that link H. pylori infection to gastric carcinogenesis are not well understood. In the present study, we report that the Raf-kinase inhibitor protein (RKIP) has a role in the induction of apoptosis by H....
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Introduction: Gastrointestinal (GI) cancers are considered among the most important causes of mortality and morbidity. Helicobacter pylori infection has been proven to be highly associated with the development of a variety of gastric diseases such as chronic gastritis, peptic ulcer disease (PUD), mucosa-associated lymphoid tissue (MALT), and gastric cancer (GC). To date, the exact role of the v...
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Helicobacter pylori has been the subject of intense investigation since its culture from a gastric biopsy in 1982. From the beginning, this gram-negative bacterium has provoked the interest of bacteriologists, gastroenterologists, infectious disease specialists, cancer biologists, epidemiologists, pathologists, and pharmaceutical scientists. Pathologists were among the first groups of scientist...
متن کاملHelicobacter pylori and Gastric Cancer.
Gastritis caused by infection with Helicobacter pylori (H. pylori) is one of the most common infectious diseases worldwide. There are data on the epidemiology, pathophysiology, and histology of this disease that show that H. pylori gastritis has an important role in gastric carcinogenesis. However, it has to be considered that only very few of those infected with H. pylori will develop gastric ...
متن کاملHelicobacter pylori and Gastric Cancer
Existence of any infectious agents in stomach was a big query among the microbiologists and gastroenterologists (1–3). Helicobacter pylori (H. pylori) is a leading cause of severe digestive disease, including gastric cancer (4, 5). Although over the last years, incidence of gastric carcinoma is decreasing worldwide, it remains the fourth most common cancer and the second most common cause of ma...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0037819